Teritary Structure New Break Thru...

For Years.. Bioinformatician has been trying to solve the great mystery of the structure of a protein by prediction
In the past.. experts used to say.. To determining the shape of a protein!, is just a matter of firing X-ray Beam @_@ at its crystalline form and measure it... and!! chemists are way too sceptical to prove him WRONG!
Until recently .. recently...
Ah AH!! on 14/10/2007!~~ David Baker!,
A biochemist at Uni of Washington, and his colleagues found astonishing result! to prove what the experts sayd WRONG!!.. breaking the scepticism in the chemist's world!
Baker came out with a new techique, which combines information from the sum of
By : what is already known about the structure with the vast com - power available
{ what this means? => getting 150k of volunteers to use his program at home }
Soo.. how this program works?
In Basic :1) Breaks the protein sequence into small stretches
2) Match the stretches with all the known protein structures {Logically, if a result = very 100% = its also be 100% accurate}
3) minimize the free energy of the structure so to measure its stability!
4) Repeat all this steps Over and Over Again UNTIL! it lurch towards an ever more Accurate Protein Model!~ Woo{Theres too much data in the world of the web, so if they could get everything done, which will take quite sometime..result would be darn good.}
And this program is called....BOINC

So In full, Its like u take a sequence, with 112 amino acid protein for example,the Network will breakup it up into several million structures, "with some very long time"this Millions of structure will then be whittled down to 5{6 Zeros digit to 5... @_@!}
until 1 structure is found, it will then relate its structure with its determined structure frm its crytsal
But.. Even after this..., result might not be as precision as the cyrstal, BUT!least its good enough to "throw away" the X-ray techique.
Even so... theres still room for improvement,but for now.. the structure prediciton would be the prospect of custom-made proteins.which is used to hunt for sequence that correspond to the desired structures.
Now.. the team os currently redesigning the gp120 Protein of HIV,hoping to make a vaccine that could stimulate the immune system in a different wayfrom the nature of the virus,if this is possible.. "the reshaped protein should attack the virus more effectively then antibodies created"{If Success, i believe.. human, will no longer regard the danger HIV will cause, after all.. our heart contains 7 deadly sinson the other hand, innocent child, might be saved.... }

Baker's Words.."The days when protein modellers thoughtthey could make crystallization obsolete arelong gone"

“If you reallycare about the structure of your protein, youshould get some experimental data and combineit with modelling"
So, by the way things are progressing, "light" will soon be seem by us..

For more info : Rosetta@Home
For more info on Ppl helping out with BOINC : http://www.youtube.com/watch?v=GzATbET3g54

Bye Bye!
Post by Zhong En